Does Thymectomy Benefit Patients With Myasthenia Gravis?
Does thymectomy benefit patients with myasthenia gravis? To find out, Wolfe and colleagues conducted a large, multicenter, randomized trial comparing conventional prednisone treatment (n = 60) with prednisone plus thymectomy (n = 66). Patients were followed for 3 years; outcome measures were disease severity and required prednisone dose. Patients were between 18 and 64 years of age, and about 70% were female. The median duration of disease prior to trial entry was 1 year. Through month 36, the clinical status of patients in the surgery group was significantly better than in the nonsurgery group (P = .001), and the use of prednisone in the surgery group was significantly less than in the nonsurgery group (P = .001).